A review of ANO1-based calcium activated chloride channel modulators
10.16438/j.0513-4870.2017-0386
- VernacularTitle:以ANO1蛋白为靶点的钙激活氯通道调节剂研究进展
- Author:
Yu-xi WANG
1
;
Zhen-ming LIU
1
;
Gui-sen ZHANG
2
;
Liang-ren ZHANG
1
Author Information
1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmacy, Peking University, Beijing 100191, China
2. Jiang Su Enhwa Drug Research Institution, Xuzhou 221100, China
- Publication Type:REVIEWS
- Keywords:
calcium-activated chloride channel;
anoctamin 1;
modulators;
structure-activity relationship;
bio-test methods;
application
- From:
Acta Pharmaceutica Sinica
2017;52(10):1505-1514
- CountryChina
- Language:Chinese
-
Abstract:
Calcium-activated chloride channel (CaCC) is an anion channel, widely distributed in the human body, taking a part in cell functions including secretion, heart muscle repolarization, nerve signal transmission and several physiological activities. The anoctamin 1 (ANO1) protein is the molecular basis of CaCC and the modification of ANO1 protein will produce a variety of pharmacological effects, such as analgesia, treating dysentery and asthma, even tumor proliferation and migration inhibition. In the past decade, many methods in screening of ANO1 regulators have been developed. Although a series of the ANO1-based CaCC regulatory molecules have been identified, the pharmacological effects of these molecules are not consistent. In this review, we introduce ANO1 protein regulators from many aspects including bio-test methods, structure-activity relationships, and the potential applications.
