Research progress in toxic effects of antitumor drugs based on drug transporter
10.16438/j.0513-4870.2017-0470
- VernacularTitle:药物转运体介导的抗肿瘤药物毒性反应的研究进展
- Author:
Jin-qi ZHENG
1
;
Xi YANG
1
;
Qian WANG
1
;
Jun ZHOU
1
;
Yan LOU
1
;
Su ZENG
2
Author Information
1. The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310000, China
2. Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
- Publication Type:REVIEWS
- Keywords:
antitumor drug;
transporter;
toxic effect;
genetic polymorphism
- From:
Acta Pharmaceutica Sinica
2017;52(10):1496-1504
- CountryChina
- Language:Chinese
-
Abstract:
Differences of the individual toxic effects of antitumor drugs have been a concern in clinical treatment of cancers. The drug toxicity was not only related to the age, sex, and drug interactions, but also to the expression of protein involved in the metabolism, targets and transporters of drugs. Drug transporter mediates the absorption, distribution and elimination of some drugs, which exhibits a great significance in pharmacology and clinical practice. The purpose of this review is to provide information regarding trans-porter-medicated toxic effects of antitumor drugs in order to reduce or avoid the transporter-medicated toxic effects, and to promote reasonable drug use and individualized application of antitumor drugs in clinics.
