Role of FMOs in drug metabolism and development
10.16438/j.0513-4870.2017-0231
- VernacularTitle:黄素单氧化酶在药物代谢和新药研发中的作用
- Author:
Ya-kun YANG
1
;
Li SHENG
1
;
Yan LI
1
Author Information
1. Department of Drug Metabolism, Beijing City Key Laboratory of Non-Clinical Drug Metabolism and PK/PD Study, Beijing City Key Laboratory of Active Substances Discovery and Drug Ability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:REVIEWS
- Keywords:
flavin-containing monooxygenase;
cytochrome P450;
gene polymorphism;
individual differ-ence;
drug metabolism;
new drug development
- From:
Acta Pharmaceutica Sinica
2017;52(10):1485-1495
- CountryChina
- Language:Chinese
-
Abstract:
The flavin-containing monooxygenase (FMOs) is recognized as an important complimentary enzyme system next to the cytochrome P450 (CYP450), which catalyzes the metabolism of many xenobiotics (nucleophilic heteroatom-containing chemicals) and several endobiotics. This article provides a comprehensive introduction of FMOs including the biological characteristics, catalytic mechanism, substrate specificity, genetic polymorphisms. The effect of FMOs on drug metabolism and individual differences and relation with diseases are also mentioned. It is valuable for the discovery of therapeutic targets and design of new drug candidate.
