Studies on the chemical constituents of the anti-osteoporotic part of Lepidium meyenii Walp. produced in Heqing
10.16438/j.0513-4870.2017-0033
- VernacularTitle:鹤庆产黄玛咖抗骨质疏松活性部位的化学成分研究
- Author:
Yan-mei LIU
1
;
De ZHAO
2
;
Meng-meng XIAO
1
;
Jun DENG
1
Author Information
1. College of Pharmaceutical Sciences and Chinese Medicine, Southwest University, Chongqing 400715, China
2. Chongqing Honoroad Animal Health Co. Ltd, Chongqing 401519, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
Lepidium meyenii;
Brassicaceae;
chemical constituents;
macaolidine
- From:
Acta Pharmaceutica Sinica
2017;52(6):943-947
- CountryChina
- Language:Chinese
-
Abstract:
This study was designed to investigate the chemical constituents of the anti-osteoporotic part of Lepidium meyenii Walp. (maca) produced in Heqing, Yunnan. Seven compounds were isolated from the n-BuOH extract of maca using combination of column chromatographies on MCI resin, silica gel, C18 bonded silica gel, and Sephadex LH-20, followed by semi-preparative HPLC and recrystallization. The purified compounds were identified on the basis of their physicochemical properties and spectral data as macaolidine (1), tryptophan (2), daucosterol (3), (3S)-1,2,3,4-tetrahydro-β-carboline-3-carboxylicacid (4), chlorogenic acid (5), luteolin (6), and hyperoside (7). Compound 1 is a new phenylacetamide alkaloid, and compounds 4-7 were isolated from Lepidium meyenii for the first time.
