Advances of antineoplastic agents based on mitochondrial targeting mechanism
10.16438/j.0513-4870.2017-0177
- VernacularTitle:基于线粒体靶向机制的抗肿瘤制剂的研究进展
- Author:
Ai-yun LIU
1
;
Xiao-shuang HOU
1
;
Ya DING
1
Author Information
1. Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, China Pharmaceutical University, Nanjing 210009, China
- Publication Type:REVIEWS
- Keywords:
neoplasms;
mitochondria;
targeting;
mitochondrial membrane potential;
mitochondrial outer membrane permeabilization;
preparation with positive charge;
Bcl-2 protein
- From:
Acta Pharmaceutica Sinica
2017;52(6):879-887
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondrion is an important organelle in cells and plays a crucial role in tumor development. Therefore, improvement of the targeting ability of anticancer drugs to mitochondria will increase the treatment efficacy for tumor and reduce the side effect on normal tissues. Here, research progresses in mitochondrial targeting have been reviewed in three aspects for tumors treatment: the potential, permeability and translocase of mitochondrial membrane. The review provides a reference for the development of mitochondria targeted therapeutic systems.
