Research progress of pharmacokinetics of metformin based on transporters
10.16438/j.0513-4870.2016-1148
- VernacularTitle:基于药物转运体机制的二甲双胍体内过程研究进展
- Author:
Xi-ning XU
1
;
Rong SHI
1
;
Yue-ming MA
1
Author Information
1. College of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
- Publication Type:REVIEWS
- Keywords:
transporter;
metformin;
pharmacokinetics;
drug-drug interaction;
organic cation transporter;
multidrug and toxin extrusion protein
- From:
Acta Pharmaceutica Sinica
2017;52(6):865-870
- CountryChina
- Language:Chinese
-
Abstract:
Drug transporters play vital roles in absorption, distribution and excretion of drugs. Understanding the transport activity can improve the effectiveness and safety of drugs and guide clinical rational use of drugs. Metformin is a first-line drug in the treatment of type 2 diabetes mellitus, of which the pharmacokinetics involves several transporters. The changes in expression and function of these transporters affect directly the pharmacokinetics/pharmacodynamics of metformin. This paper reviews the research progress of pharmacokinetics of metformin based on transporters, and these transporters are organic cation transporters (OCTs), multidrug and toxin extrusion proteins (MATE), plasma membrane monoamine transporter protein (PMAT), serotonin reuptake transporter (SERT), thiamine transporter 2 (THTR-2), and carnitine/organic cation 1 (OCTN1).
