Research progress of environment-responsive delivery system in the application of co-delivery gene and drug
10.16438/j.0513-4870.2017-0008
- VernacularTitle:环境响应性递释系统在基因与药物共传递应用中的研究进展
- Author:
Dun FAN
1
;
Jing-mou YU
1
;
Hao HUANG
2
;
Yi JIN
3
Author Information
1. School of Pharmacy and Life Science, Jiujiang University, Jiujiang 332000, China
2. School of Chemical and Biological Engineering, Yichun University, Yichun 336000, China
3. National Engineering Research Center for Manufacturing Technology of TCM Solid Preparation, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China
- Publication Type:REVIEWS
- Keywords:
co-delivery system;
environment-responsive;
nanoscaled carrier;
triggered release;
antitumor
- From:
Acta Pharmaceutica Sinica
2017;52(5):713-721
- CountryChina
- Language:Chinese
-
Abstract:
With the development of polymeric materials and nanotechnology, the potential application of nanoscaled drug delivery system (NDDS) is gradually manifested in the field of pharmaceutics. Especially, NDDS has the obvious advantages in the delivery of gene or drug. Comparing to the delivery system of single-drug, co-delivery system of gene and drug can significantly improve the therapeutic effects by enhancing transfection efficiency of gene and reversing multidrug resistance, etc. The co-delivery systems of gene and drug, which had the triggered release characteristics in the inner and outer of tumor, could be constructed by introducing the environment-responsive (pH-responsive, redox-responsive and light-responsive, etc) groups into the co-delivery system. The antitumor activity was further improved. In the present paper, the environment- responsive delivery systems in the application of co-delivery gene and drug in recent years were reviewed, and their remarkable properties in the antitumor activity were analyzed and summarized.
