Crystal structure and crystal form stability of trelagliptin succinate
10.16438/j.0513-4870.2016-0452
- VernacularTitle:曲格列汀琥珀酸盐晶体结构和晶型稳定性研究
- Author:
Jia-li YE
1
;
Xin-bo ZHOU
1
;
Su-xiang WU
1
;
Meng-ying SUN
1
;
Jian-ming GU
2
;
Xiu-rong HU
2
Author Information
1. College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 310053, China
2. Department of Chemistry, Zhejiang University, Hangzhou 310028, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
trelagliptin hemi-succinate;
trelagliptin succinate;
crystal structure;
stability;
transformation
- From:
Acta Pharmaceutica Sinica
2016;51(11):1759-
- CountryChina
- Language:Chinese
-
Abstract:
In order to investigate trelagliptin succinate's stability in solution, recrystallization and suspension methods in polar solvent (mainly in water and 95% alcohol) were used to study the crystal form transformation of trelagliptin succinate. Single crystal X-ray diffraction, powder X-ray diffraction and thermalgravimetric analysis, and differential scanning calorimetry were used to characterize the structure of the solid state form before and after transformation. The results showed that trelagliptin succinate can easily convert to trelagliptin hemi-succinate mediated by solvent, especially by polar solvent, namely trelagliptin hemi-succinate is more stable than trelagliptin succinate in solution.
