Associations of SLCO1B1 polymorphisms with tacrolimus concentrations in Chinese renal transplant recipients
10.16438/j.0513-4870.2016-0027
- VernacularTitle:SLCO1B1基因多态性与肾移植患者他克莫司浓度相关性的研究
- Author:
Shu LIU
1
;
Rong-xin CHEN
2
;
Jun LI
3
;
Xiao-man LIU
4
;
Hong-bing HUANG
1
;
Qian FU
3
;
Chang-xi WANG
3
;
Min HUANG
4
;
Jia-li LI
4
Author Information
1. Cancer Center, State Key Laboratory of Oncology in South China;Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University, Guangzhou 510060, China
2. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China
3. Kidney Transplant Department, Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510060, China
4. Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510060, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
tacrolimus;
SLCO1B1;
single nucleotide polymorphism;
renal transplantation;
calcineurin inhibitor
- From:
Acta Pharmaceutica Sinica
2016;51(8):1240-
- CountryChina
- Language:Chinese
-
Abstract:
The study aims to investigate the associations of SLCO1B1 polymorphisms with tacrolimus concentrations in Chinese renal transplant recipients. Blood samples and clinical data were collected from 89 renal transplant recipients with tacrolimus treatment. CYP3A5*3 genotypes were detected by PCR-RFLP method and SLCO1B1 (rs2306283, rs4149032) genotypes were detected by Agena Bioscience Mass ARRAY ® system. Trough concentrations of tacrolimus on day 7 after renal transplantation were collected from clinical data. Correlations between genetic polymorphisms and tacrolimus concentrations were analyzed by SPSS. In CYP3A5 nonexpressers, the dose-adjusted concentration of tacrolimus in SLCO1B1 rs2306283 CC carriers was considerably higher than that in CT and TT carriers. The results illustrated that SLCO1B1 rs2306283 polymorphisms were associated with tacrolimus concentrations, and genotyping for this SNP may be usefulfo r individualized medicine of tacrolimus.
