Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 1 and T cell migration
10.16438/j.0513-4870.2016-0293
- VernacularTitle:1-磷酸鞘氨醇/1-磷酸鞘氨醇受体1与T细胞迁移
- Author:
Xin-pin ZHUANG
1
;
Qing ZHU
1
Author Information
1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:REVIEWS
- Keywords:
sphingosine-1-phosphate;
sphingosine-1-phosphate receptor 1;
T cell migration;
drug target
- From:
Acta Pharmaceutica Sinica
2016;51(6):873-
- CountryChina
- Language:Chinese
-
Abstract:
Lipid second messenger sphingosine-1-phosphate (S1P) can activate sphingosine-1-phosphate receptors (S1PRs) and participate in many biological processes, such as central nervous system homeostasis, cytokine production and T cell migration. S1PR1 is the main S1PR expressed on T cell surface. The interaction between S1P and S1PR1 plays a core role in T cell migration, which is important for T cell maturation, homing and activation. The central function of S1P/S1PR1 in T cell migration made it a popular drug target in treatment research of immune diseases. This review summarizes the current knowledge of the mechanism of S1P/S1PR1 mediating T cell migration and the research progress of S1P/S1PR1 as drug target.
