Progress in regulation of drug transporters and metabolic enzymes by resveratrol
10.16438/j.0513-4870.2015-0976
- VernacularTitle:白藜芦醇对药物转运体和代谢酶影响的研究进展
- Author:
Yong-ming JIA
1
;
Zhi-hao LIU
1
;
Ke-xin LIU
1
Author Information
1. College of Pharmacy, Dalian Medical University, Dalian 116044, China
- Publication Type:REVIEWS
- Keywords:
transporter;
metabolic enzyme;
resveratrol;
drug-drug interaction
- From:
Acta Pharmaceutica Sinica
2016;51(6):860-
- CountryChina
- Language:Chinese
-
Abstract:
Drug transporters and metabolic enzymes are two major factors in the regulation of disposition of drug in the body. Interestingly, resveratrol, as a new star of anticancer drug, has a close relationship with transporters and metabolic enzymes. It is known that resveratrol can activate or inhibit the function of several transporters directly. Furthermore, the expression of several transporters was changed. Meanwhile, resveratrol is able to inhibit the function of metabolic enzymes (cytochrome P450, CYP450) and regulate the expression of metabolic enzymes. For this reason, when resveratrol is administrated in combination with other drugs, drug-drug interaction (DDI) should be considered. In this review, we summarize the distribution of transporters and metabolic enzymes in the body, the effect of resveratrol on transporters and metabolic enzymes as well as the drug-resveratrol interaction mediated by transporters and metabolic enzymes.
