Degradation kinetics of chlorogenic acid, cryptochlorogenic acid, and neochlorogenic acid at neutral and alkaline pH values
10.16438/j.0513-4870.2015-0446
- VernacularTitle:绿原酸、隐绿原酸和新绿原酸在中性和碱性pH条件下的降解动力学
- Author:
Peng ZHU
1
;
Xiao-lei MIAO
1
;
Yong CHEN
1
Author Information
1. Hubei Province Key Laboratory of Biotechnology of Chinese Traditional Medicine, Hubei Collaborative Innovation Center for Green Transformation of Bio-resources, Hubei University, Wuhan 430062, China
- Publication Type:ORIGINAL ARTICLES
- Keywords:
chlorogenic acid;
cryptochlorogenic acid;
neochlorogenic acid;
degradation kinetics;
Weibull equation
- From:
Acta Pharmaceutica Sinica
2016;51(1):122-
- CountryChina
- Language:Chinese
-
Abstract:
The degradation kinetics of chlorogenic acid (5-CQA), cryptochlorogenic acid (4-CQA), and neochlorogenic acid (3-CQA) in aqueous solution at 37 ℃ and different pH values (7.05, 7.96, 9.25) were investigated in the present work. The results indicated that 3-, 4- and 5-CQA tended to remain stable in acidic pH circumstance, and unstable in neutral and alkaline pH circumstance. With the increase of the alkalinity, the degradation of 3-, 4- and 5-CQA was increased leading to a less amount of total CQA and was satisfactorily described by the Weibull equation. Meanwhile, caffeic acid was not detected after the degradation of CQA. Moreover, the degradation of 3-CQA and 5-CQA tended to be converted to 4-CQA, and the degradation of 4-CQA tended to be converted to 3-CQA rather than 5-CQA. The comparison of the degradation kinetics parameters of 3-, 4- and 5-CQA at neutral and alkaline pH values showed that the orders of the rate constant (k) values were 4-CQA > 3-CQA > 5-CQA, while the orders of the degradation half life (t1/2) values were 4-CQA < 3-CQA < 5-CQA, indicating the orders of the stabilities of 3-, 4- and 5-CQA at 37 ℃ and neutral and alkaline pH values were 4-CQA < 3-CQA <5-CQA.
