The regulatory role of autophagy in tumor process
10.16438/j.0513-4870.2015-0809
- VernacularTitle:自噬在肿瘤发生与发展过程中的调节作用
- Author:
Hong LIU
1
;
Rong-guang SHAO
1
Author Information
1. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:SPECIAL REPORTS
- Keywords:
autophagy;
tumor;
tumor therapy
- From:
Acta Pharmaceutica Sinica
2016;51(1):23-
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is a classical regulatory mechanism of energy metabolism and self-update system in the maintenance of the intracellular homeostasis and cell development. Autophagy has been recently found to play a role in tumor development. Autophagy regulates tumor formation, proliferation, metastasis, and metabolism. At the same time, the anticancer drugs formed with autophagic mediators have been used in the treatment, which suggested that improving autophagy activity to inhibit tumor has become a new way for cancer treatment of cancer patients. This article gives an overview of the regulatory mechanism of autophagy, the relationship between autophagy and tumor, and tumor therapy by targeting autophagy.
