Effects of resveratrol-induced cellular autophagy in control of neurodegenerative diseases
10.16438/j.0513-4870.2015-0660
- VernacularTitle:白藜芦醇诱导细胞自噬在神经退行性疾病进展中的作用
- Author:
Wen DONG
1
;
Rong WANG
1
Author Information
1. Central Laboratory, Xuanwu Hospital of Capital Medical University, Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Key Laboratory for Neurodegenerative Disease of Ministry of Education, Beijing Geriatric Medical Research Center, Beijing 100053, China
- Publication Type:SPECIAL REPORTS
- Keywords:
resveratrol;
silent information regulator 1;
deacetylate;
autophagy;
neurodegenerative disease;
aggregate
- From:
Acta Pharmaceutica Sinica
2016;51(1):18-
- CountryChina
- Language:Chinese
-
Abstract:
Cellular autophagy is a major degradative pathway for clearance of aggregate-prone proteins and damaged organelles. It plays an important role in regulating cellular homeostasis, cell growth and development, and disease development. Dysfunctional autophagy contributes to the pathology of various neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and Huntington's disease, in which specific pathological protein accumulation occurs. A growing body of evidence suggests that resveratrol plays a significantly role in the regulation of autophagy and clearance of pathological proteins. Resveratrol is a potential drug for neurodegenerative diseases therapy. This review focuses on the effects of resveratrol on cellular autophagy and clinical application in the control of neurodegenerative diseases.
