Non-autophagic degradation roles of autophagy receptors
10.16438/j.0513-4870.2015-0944
- VernacularTitle:自噬受体介导的非自噬降解功能研究进展
- Author:
Da-wei WANG
1
;
Bin ZHANG
2
;
Bin LÜ
2
;
Guang-xin WANG
3
Author Information
1. Department of Biochemistry and Molecular Biology, Shandong University, Jinan 250012, China
2. Department of General Surgery, Qilu Hospital, Shandong University, Jinan 250012, China
3. Medical Institute of Paediatrics, Qilu Children's Hospital, Shandong University, Jinan 250012, China
- Publication Type:SPECIAL REPORTS
- Keywords:
autophagy;
receptor;
ubiquitin;
apoptosis;
NF-κB
- From:
Acta Pharmaceutica Sinica
2016;51(1):1-
- CountryChina
- Language:Chinese
-
Abstract:
A growing body of evidence has indicated the important role of autophagy receptors in directing ubiquitinated or non-ubiquitinated cargos towards autophagy. Autophagy receptors bind to LC3 (microtubule- associated protein 1 1ight chain 3) on phagophore and autophagosome membranes, and recognize signals on cargoes in the delivery system of autophagy. However, the diverse domains in the receptor structures determine that their roles would never be limited to autophagy. Up to date, increasing numbers of the receptor proteins have been demonstrated to serve as a molecular link or switch participating in autophagic degradation, apoptosis or cell survival signals. Here, we highlight the non-autophagic roles of these receptor proteins to draw attention to this growing research topic.
