Epigenetic regulation of hepatitis B virus cccDNA and related prospects for antiviral therapy
10.3969/j.issn.1001-5256.2019.06.004
- VernacularTitle:HBV cccDNA转录调控机制与抗HBV治疗前景
- Author:
Juan CHEN
1
;
Ailong HUANG
Author Information
1. Key Laboratory of Molecular Biology of Infectious Diseases Designated by the Chinese Ministry of Education, Chongqing Medical University, Chongqing 400016, China
- Publication Type:Research Article
- Keywords:
hepatitis B virus;
gene regulatory networks;
cccDNA;
genes, modifier
- From:
Journal of Clinical Hepatology
2019;35(6):1192-1196
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is stably maintained in hepatocytes in the form of minichromosome and is considered the most important cause of chronicity of HBV infection, presence of HBV after antiviral therapy, and recurrence of hepatitis after drug withdrawal. However, due to a lack of antiviral regimens targeting cccDNA itself or the formation and transcription of cccDNA, there is an urgent need for treatment strategies targeting cccDNA. With the gradual understanding of epigenetic modification of histones of the cccDNA minichromosome, epigenetic therapy is expected to become a potential therapy for HBV. This article reviews the current status and future directions of HBV DNA methylation and cccDNA-bound histone modification, in order to provide new thoughts for epigenetic therapy for HBV.
