Mechanism of the activation of hepatic stellate cells: An exploration of new diagnostic markers and therapeutic targets for liver fibrosis
10.3969/j.issn.1001-5256.2019.03.042
- VernacularTitle:肝星状细胞的活化机制——探寻肝纤维化新的诊断指标和治疗靶点
- Author:
Na JIANG
1
;
Jian PING
;
Lieming XU
Author Information
1. Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
- Publication Type:Research Article
- Keywords:
hepatic stellate cells;
cytokines;
peroxisome proliferator-activated receptors;
microRNAs;
review
- From:
Journal of Clinical Hepatology
2019;35(3):640-643
- CountryChina
- Language:Chinese
-
Abstract:
Liver fibrosis has a complex pathogenesis, and at present, the research mainly focuses on hepatic stellate cells (HSC). Many stimulating factors and regulatory pathways have been found to promote the activation of HSC. This article reviews the recent research findings on several major cytokines and peroxisome proliferator-activated receptor γ and research hotspots in recent years, including the association of microRNAs, long non-coding RNA, and exosomes with HSC activation. This article also introduces potential targets for the treatment of liver fibrosis and new markers for noninvasive diagnosis of liver diseases and proposes that chemical drugs or traditional Chinese medicine compounds which act on the targets of HSC activation can be formulated, in order to make a breakthrough in the therapeutics of liver fibrosis.
