Investigation on neutralizing antibody level of Japanese encephalitis virus in adults from Guizhou Province
10.16462/j.cnki.zhjbkz.2019.02.024
- Author:
Su-ye ZHAO
1
;
Chun-ting LIU
;
Yu WANG
;
Ming LIU
;
Wei-jia JIANG
;
Hua GUO
Author Information
1. Guizhou Provincial Center for Disease Control and Prevention, Guiyang 550004,China
- Publication Type:Journal Article
- Keywords:
Japanese encephalitis;
Adults;
Neutralizing antibodies;
Plaque reduction neutralization test
- From:
Chinese Journal of Disease Control & Prevention
2019;23(2):241-244
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the level of neutralizing antibodies against Japanese encephalitis (JE) virus in adults from Guizhou Province. Methods A multi-stage random sampling method was used to collect 360 serum of healthy adults in 6 age groups of 3 cities (states) from May to June 2017. Neutralizing antibodies against Japanese encephalitis virus of healthy adults were detected by plaque reduction neutralization test. Results The positive rate of neutralizing antibodies against Japanese encephalitis virus was 55.28%, and the geometric mean titer (GMT) was 1 :17.52 in 360 subjects. The difference of the positive rates of neutralizing antibodies against Japanese encephalitis virus of adults in different genders(2=10.798, P=0.001) and in different incidence regions(2=6.090, P=0.048)was statistically significant(both P<0.05). The positive rate of different age groups was 45.00%-60.00%(2=4.236, P=0.516). The positive rate of Buyi nationality was the highest (79.17%). Conclusions The level of neutralizing antibodies against Japanese encephalitis virus of adults in Guizhou province is low, and there is a risk of epidemic encephalitis in adults.
