Involvement of intrathecal activation of MrgC receptor in pathological pain and morphine tolerance.
- Author:
You-Ping LI
1
;
Jian-Ping JIANG
2
Author Information
1. College of Life Sciences, Fujian Normal University, Fujian Key Laboratory of Developmental and Neuro Biology, Fuzhou 350117, China.
2. College of Life Sciences, Fujian Normal University, Fujian Key Laboratory of Developmental and Neuro Biology, Fuzhou 350117, China. jjp@fjnu.edu.cn.
- Publication Type:Journal Article
- MeSH:
Animals;
Drug Tolerance;
Ganglia, Spinal;
Humans;
Mice;
Morphine;
pharmacology;
Pain;
Peptide Fragments;
Rats;
Rats, Sprague-Dawley;
Receptors, G-Protein-Coupled;
physiology;
Trigeminal Ganglion
- From:
Acta Physiologica Sinica
2019;71(5):741-748
- CountryChina
- Language:Chinese
-
Abstract:
Rodent MrgC receptor (Mas-related G-protein-coupled receptor subtype C) shares 65% sequence homology and similarities in terms of expression pattern and binding profile with human Mas-related gene X receptor 1 (hMrgX1). Therefore, researchers generally explore the role of hMrgX1 by studying the function of MrgC receptor. Murine MrgC receptor is uniquely expressed in small-diameter neurons of dorsal root ganglia (DRG) and trigeminal ganglia (TG), which is closely related to the transmission process of pain. This review summarizes the analgesic effects of intrathecal activation of MrgC receptors in pathological pain and morphine tolerance.
