Research progress on and behaviors of poorly soluble Chinese materia medica nanosuspension.
10.19540/j.cnki.cjcmm.20180726.017
- Author:
Bao-de SHEN
1
;
Cheng-Ying SHEN
2
;
Ling-Xia XU
1
;
Wei-Feng ZHU
1
;
Hai-Long YUAN
2
Author Information
1. Key Laboratory of Modern Preparation of Traditional Chinese Medicine (TCM), Ministry of Education, Jiangxi University of TCM, Nanchang 330004, China.
2. Department of Pharmacy, Air Force General Hospital, PLA, Beijing 100142, China.
- Publication Type:Journal Article
- Keywords:
Chinese materia medica;
in vitro/vivo behavior;
nanosuspension;
preparation method;
research progress
- MeSH:
Biological Availability;
Drug Delivery Systems;
Materia Medica;
chemistry;
Medicine, Chinese Traditional;
Nanoparticles;
Particle Size;
Solubility;
Suspensions
- From:
China Journal of Chinese Materia Medica
2018;43(19):3828-3833
- CountryChina
- Language:Chinese
-
Abstract:
Nanosuspension (also called nanocrystal suspension or nanocrystal) could significantly enhance the saturated solubility and dissolution of insoluble drugs, and improve their bioavailability by reducing particle size and increasing the specific surface, which could then solve the delivery problems of the poorly soluble active ingredients and effective parts of Chinese materia medica (CMM). Based on the brief summaries of nanosuspension preparation methods, this paper would mainly review the and behaviors of poorly soluble CMM nanosuspension, discuss and analyze its problems, so as to provide reference and thinking for the further study of nanosuspension drug delivery system of poorly soluble CMM and promote the development and perfection of nanosuspension technology in CMM.
