Size Estimation of HLA -Ⅰ class Typed Platelet Apheresis Donor Bank.
10.7534/j.issn.1009-2137.2019.01.043
- Author:
Min XUE
1
,
2
;
Qin-Qin PAN
3
;
Su FAN
3
;
Xiao-Yan WANG
3
;
Fang ZHAO
4
;
Tai-Xiang LIU
4
;
Li-Li SHI
4
;
Ling MA
4
;
Jie SHENG
3
Author Information
1. Jiangsu Province Blood Center，Nanjing 210042，Jiangsu Province, China.E-mail：13905185030@
2. com.
3. Department of HLA, Jiangsu Province People's Hospital, Nanjing 210036, Jiangsu Province，China.
4. Jiangsu Province Blood Center，Nanjing 210042，Jiangsu Province, China.
- Publication Type:Journal Article
- MeSH:
Bone Marrow;
Bone Marrow Transplantation;
HLA Antigens;
Histocompatibility Testing;
Humans;
Plateletpheresis;
Registries;
Tissue Donors
- From:
Journal of Experimental Hematology
2019;27(1):266-271
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To estimate the size of HLA -Ⅰ class typed platelet apheresis donor bank.
METHODS:A total of 16062 blood samples from Chinese Han voluntary unrelated marrow donors in Jiangsu were included in this study. Luminex-SSO was used to detect the HLA -Ⅰ class(A,B locus) antigens. The probability of finding at least one HLA matched unrelated donor was calculated based on the HLA -I class phenotype frequency.
RESULTS:The population genetic data of HLA -Ⅰ class in Jiangsu were obtained, the optinal bans size in HLA typed apheresis plateler donor registry databane hrad been estimated by evaluating the population genetic data of HLA-1 class same donor.
CONCLUSION:The establishment of HLA-1 class typed apheresis platelet donor bank with a total size of 1500 persons is acceptable, which can satisty the patients with phenotype freguency>0.002 to find at least 1 phenotype same donor in 95% probavility.
