Peripheral T-cell Lymphomas: Updates in Allogeneic Hematopoietic Stem Cell Transplantation.
- Author:
Wen-Rong HUANG
1
;
Dai-Hong LIU
1
Author Information
- Publication Type:Journal Article
- Keywords: Allogeneic; Hematopoietic Stem Cell Transplantation; Peripheral T-cell Lymphoma; Survival
- MeSH: Graft vs Host Disease; prevention & control; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma, T-Cell, Peripheral; therapy; Neoplasm Recurrence, Local; Transplantation Conditioning; Transplantation, Homologous
- From: Chinese Medical Journal 2018;131(17):2105-2111
- CountryChina
- Language:English
-
Abstract:
Objective:Peripheral T-cell lymphomas (PTCLs) confer dismal prognosis and no consensus has been established on the role of allogeneic hematopoietic stem cell transplantation (allo-HSCT) due to its rarity and heterogeneity. The purpose was to review key points of allo-HSCT for PTCLs, including indication, times of transplantation, conditioning regimen, graft versus host disease prophylaxis, and treatment of relapse.
Data Sources:A comprehensive search in PubMed and Cochrane up to February 28, 2018, with the keywords "Peripheral", "T", "Lymphoma", and "Transplantation" was done.
Study Selection:Relevant articles including HSCT for PTCLs were carefully reviewed.
Results:Promising data have been reported from advances in transplant technology and more and more PTCLs patients with poor prognosis could benefit from allo-HSCT.
Conclusion:Allo-HSCT is a useful choice for patients with refractory/relapsed PTCLs or high-risk new diagnosed PTCLs.
