Mechanisms and implications of cancer cell dormancy in head and neck carcinoma.

Gao XIAOLEI; Liang XINHUA; Tang YALING

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Mechanisms and implications of cancer cell dormancy in head and neck carcinoma.

VernacularTitle:头颈部肿瘤休眠机制的研究进展
Author: Gao XIAOLEI ¹ ; Liang XINHUA ¹ ; Tang YALING ²
Author Information

1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
2. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Pathology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Publication Type:Journal Article
Keywords: cancer dormancy; disseminated tumor cell; head and neck cancer; hypoxia; lymph-node metastasis
MeSH: Bone Marrow; Head and Neck Neoplasms; Humans; Lymph Nodes; Neoplasm Recurrence, Local; Neoplasm, Residual; Tumor Microenvironment
From: West China Journal of Stomatology 2018;36(1):92-98
CountryChina
Language:Chinese
Abstract: Disease metastasis and relapse in many cancer patients several years (even decades) after surgical remission have been recently acknowledged as cases of cancer dormancy. Although cases of minimal residual disease are well documented, knowledge on its biological mechanisms and clinical implications remains limited. To date, numerous reviews have summarized the three potential models that may explain this phenomenon, including the angiogenic, immunologic, and cellular dormancy. In this study, we discuss newly uncovered mechanisms governing tumor cell dormancy in head and neck cancer, emphasizing on the crosstalk between dormant tumor cells and their microenvironments. Additionally, we explore the mechanisms on the reactivation of dormant residual tumor cells in anatomical sites, including the lymph nodes and bone marrow.