Clinical Evaluation of A New Pathological Classification for
Non-small Cell Lung Cancer Based on Histogenesis of Bronchial Tree.
10.3779/j.issn.1009-3419.2018.07.05
- Author:
Nana WANG
1
;
Nan JIANG
2
;
Xiaoqing YANG
1
;
Lei FANG
1
;
Qing SUN
1
Author Information
1. Department of Pathology, Qianfoshan Hospit al Affiliated to Shandong University, Jinan 250000, China.
2. Department of Pathology, Shandong Provincial Hospital West Hospital, Jinan 250022, China.
- Publication Type:Journal Article
- Keywords:
EGFR;
Histogenesis;
Lung neoplasms;
Pathological classification
- MeSH:
Aged;
Bronchi;
pathology;
Carcinoma, Non-Small-Cell Lung;
classification;
pathology;
Female;
Humans;
Lung Neoplasms;
classification;
pathology;
Male;
Middle Aged
- From:
Chinese Journal of Lung Cancer
2018;21(7):530-535
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Due in part to remarkable advances over the past decade in our understanding of lung cancer, there is a pressing need for a revised classification. The aim of this study was to explore and verify the clinical significance of a new molecular classification of non-small cell lung cancer (NSCLC) on the basis of anatomic site of bronchial tree.
METHODS:Double-immunohistochemistry were performed in 105 tumor samples paring with normal lung tissue from non-small cell lung cancer patients by using monoclonal antibody of P63/NapsinA and TTF-1/CK7. By comprehensively analyzing the express profiles of tumors and normal lung tissues, histological characteristics we proposed a brand new pathological classification based on histogenesis for NSCLC and divided them as: bronchiole epithelial cell carcinoma, bronchiole-alveolar cell carcinoma, alveolar cell carcinoma and secretory adenocarcinoma. And to analyze the relationship between this classification and epidermal growth factor receptor (EGFR) mutation and ognosis.
RESULTS:Further investigation revealed that our new classification showed strong relevancy with EGFR mutations and effective indicators for prognosis.
CONCLUSIONS:The classification system for NSCLC proposed by our research group is convenient for pathological diagnosis and valuable in clinical application.
