Correlation of Epstein-Barr Virus Infection with Prognosis of Children with Acute B Lymphoblastic Leukemia.
10.19746/j.cnki.issn.1009-2137.2019.03.021
- Author:
Shi TANG
1
;
Rong ZHANG
1
;
Dan WANG
1
;
Xing-Bin WANG
1
;
E CHEN
1
;
Zhi-Dai LIU
1
;
Shan LIU
1
;
Lin ZOU
2
,
3
;
Hai-Yan LIU
4
;
Jie YU
4
Author Information
1. Clinical Molecular Center of Children's Hospital Affiliated to Chongqing Medical University;Chongqing 400014, China,Chongqing Key Laboratory of Pediatrics, Key Laboratory of Developmental Diseases of Ministry of Education; Chongqing 400014, China.
2. Clinical Molecular Center of Children's Hospital Affiliated to Chongqing Medical University;Chongqing 400014, China,Chongqing Key Laboratory of Pediatrics, Key Laboratory of Developmental Diseases of Ministry of Education; Chongqing 400014, China,E-mail: zoulin74@
3. com.
4. Chongqing Key Laboratory of Pediatrics, Key Laboratory of Developmental Diseases of Ministry of Education; Chongqing 400014, China,Blood Center of Children's Hospital Affiliated to Chongqing Medical University, Chongqing 400014, China.
- Publication Type:Journal Article
- MeSH:
B-Lymphocytes;
Child;
DNA, Viral;
Epstein-Barr Virus Infections;
Herpesvirus 4, Human;
Humans;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
Prognosis
- From:
Journal of Experimental Hematology
2019;27(3):769-776
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the correlation of EB virus infection with the prognosis of B-ALL children.
METHODS:The peripheral blood of children with newly diagnosed B-ALL admitted in Children's Hospital of Chongqing Medical University from January 2012 to December 2017 were collected, and the EBV DNA in plasma was detected by real-time quantitative PCR. The clinical data of B-ALL children were collected and the correlation of EBV infection with the prognosis of B-ALL children was analyzed.
RESULTS:Among 162 B-ALL children, the EBV infection rate was 41.36%. Univariate analysis showed that the B-ALL children with EBV infection had the poor prognosis and higher risk of shorter survival time, as compared with B-ALL children without EBV infection (HR=2.373, 95% CI: 1.129-4.987) (P＜0.05), the multivariate analysis showed that the result was consistent with result of univariate analysis indicating that EBV infection was an independent predictor for poor prognosis of B-ALL children.
CONCLUSION:The EBV infection may play an important role in the occurrence and progression of B-ALL and is an independent predictor for poor prognosis, therefore the detection of EBV DNA in plasma of B-ALL children possesses an important significance for evaluation of B-ALL children's prognosis.
