Interrelationship of Uric Acid, Gout, and Metabolic Syndrome: Focus on Hypertension, Cardiovascular Disease, and Insulin Resistance

Author: Seong Kyu KIM ¹
Author Information

1. Division of Rheumatology, Department of Internal Medicine, Arthritis and Autoimmunity Research Center, Catholic University of Daegu School of Medicine, Daegu, Korea. kimsk714@cu.ac.kr
Publication Type:Review
Keywords: Uric acid; Hyperuricemia; Gout; Metabolic syndrome
MeSH: Cardiovascular Diseases; Diabetes Mellitus; Gout; Hypertension; Hyperuricemia; Insulin Resistance; Insulin; Prevalence; Uric Acid
From:Journal of Rheumatic Diseases 2018;25(1):19-27
CountryRepublic of Korea
Language:English
Abstract: The mean serum uric acid level and the prevalence of hyperuricemia have increased over the past few decades. Hyperuricemia is considered to be responsible for the increased risk of hypertension, insulin resistance, and cardiovascular disease. Metabolic syndrome also contributes to the development of type II diabetes mellitus and cardiovascular disease. Despite the close relationships between uric acid and the components of metabolic syndrome, the causal effect of uric acid on these clinical issues is unclear. Recent studies have revealed the possible development of metabolic syndrome mediated by fructose-induced hyperuricemia. This review summarizes the available clinical and experimental data supporting the causal effect of uric acid on the components of metabolic syndrome, including hypertension, cardiovascular disease, and insulin resistance.