Effects of 3,3′,4,4′,5-pentachlorobiphenyl on human Kv1.3 and Kv1.5 channels
10.11620/IJOB.2019.44.3.115
- Author:
Jong Hui KIM
1
;
Soobeen HWANG
;
Seo In PARK
;
Su Hyun JO
Author Information
1. Department of Physiology, Institute of Bioscience and Biotechnology, BK21 Plus Graduate Program, Kangwon National University College of Medicine, Chuncheon 24341, Republic of Korea. suhyunjo@kangwon.ac.kr
- Publication Type:Original Article
- Keywords:
3,3′,4,4′,5-pentachlorobiphenyl;
Kv1.3 channel;
Kv1.5 channel
- MeSH:
Animals;
Apoptosis;
Atrophy;
B-Lymphocytes;
Carbon;
Chondrocytes;
Endocrine System;
Heart;
Humans;
Immunosuppression;
Nitric Oxide;
Polychlorinated Biphenyls;
Potassium Channels
- From:International Journal of Oral Biology
2019;44(3):115-123
- CountryRepublic of Korea
- Language:English
-
Abstract:
Among the environmental chemicals that may be able to disrupt the endocrine systems of animals and humans are polychlorinated biphenyls (PCBs), a chemical class of considerable concern. PCB consists of two six-carbon rings linked by a single carbon bond, and theoretically, 209 congeners can form, depending on the number of chlorines and their location on the biphenyl rings. Furthermore, 3,3′,4,4′,5-pentachlorobiphenyl (PCB126) exposure also increases nitric oxide production and nuclear factor kappa-light-chain-enhancer of activated B cells binding activity in chondrocytes, thus contributing as an initiator of chondrocyte apoptosis and resulting in thymic atrophy and immunosuppression. This study identified whether cardiac and immune abnormalities from PCB126 were caused by the Kv1.3 and Kv1.5 channels. PCB126 did not affect either the steady-state current or peak current of the Kv1.3 and Kv1.5 channels. However, PCB126 right-shifted the steady-state activation curves of human Kv1.3 channels. These results suggest that PCBs can affect the heart in a way that does not block voltage-dependent potassium channels including Kv1.3 and Kv1.5 directly.
