Serum Aminotransferase Level in Rhabdomyolysis according to Concurrent Liver Disease
10.4166/kjg.2019.74.4.205
- Author:
Kyeong Min JO
1
;
Nae Yun HEO
;
Seung Ha PARK
;
Young Soo MOON
;
Tae Oh KIM
;
Jongha PARK
;
Joon Hyuk CHOI
;
Yong Eun PARK
;
Jin LEE
Author Information
1. Department of Internal Medicine, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea. nyheo@hanmail.net
- Publication Type:Original Article
- Keywords:
Rhabdomyolysis;
Aspartate aminotransferases;
Alanine transaminase;
Liver diseases
- MeSH:
Alanine Transaminase;
Aspartate Aminotransferases;
Creatinine;
Hand;
Humans;
Liver Diseases;
Liver Diseases, Alcoholic;
Liver;
Muscle, Skeletal;
Phosphotransferases;
Rhabdomyolysis
- From:The Korean Journal of Gastroenterology
2019;74(4):205-211
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: The serum aminotransferase level is usually elevated in rhabdomyolysis, and these enzymes originate from the skeletal muscle. On the other hand, there is limited data showing whether the degree of elevation of these enzymes differs according to the concurrent liver disease. METHODS: Patients with rhabdomyolysis were selected when their serum creatinine kinase level was >1,000 U/L. They were categorized as the group with and without concurrent liver disease. The AST and ALT levels in both groups were compared. In addition, the aminotransferase level was compared between those with rhabdomyolysis and those with alcoholic liver disease. RESULTS: Among the 165 patients with rhabdomyolysis, 19 had concurrent liver disease. The median peak AST was higher in the group with concurrent liver disease (332 U/L [interquartile range (IQR), 127–1,604] vs. 219 U/L [IQR, 115–504]). In addition, the median peak ALT was higher in the group with concurrent liver disease (107 U/L [IQR, 74–418] vs. 101 U/L [IQR, 56–218]). On the other hand, there was no significant difference in both enzymes between the two groups. The median peak AST level was significantly higher in those with rhabdomyolysis than in those with alcoholic liver disease (221 U/L [IQR, 118–553] vs. 103 U/L [IQR, 59–206]), but the median peak ALT was not significantly different (102 U/L [IQR, 58–222] vs. 51 U/L [IQR, 26–117]). CONCLUSIONS: Rhabdomyolysis showed an elevated AST-dominant aminotransferase level, which is not different according to concurrent liver disease. Therefore, it is recommended that rhabdomyolysis be considered first in cases of elevated aminotransferase levels in patients with a suspicious skeletal muscle injury.
