Downbeat, Gaze-evoked and Perverted Head-shaking Nystagmus Associated with Dapsone Toxicity
- Author:
Tae Woo KIM
1
;
Sun Young OH
;
Ha Cheol CHOI
;
Byoung Soo SHIN
;
Man Wook SEO
;
Young Hyun KIM
Author Information
1. Department of Neurology, Chonbuk National University College of Medicine, Jeonju, Korea. ohsun@chonbuk.ac.kr
- Publication Type:Case Report
- Keywords:
Downbeat nystagmus;
Dapsone intoxication;
Head-shaking nystagmus;
Gaze-evoked nystagmus
- MeSH:
Anemia, Hemolytic;
Dapsone;
Humans;
Leprosy
- From:Journal of the Korean Balance Society
2009;8(2):161-163
- CountryRepublic of Korea
- Language:English
-
Abstract:
Dapsone is an agent commonly used to treat leprosy and its most common adverse effect is a hemolytic anemia. We present a patient who showed transient downbeat, bilateral horizontal gaze-evoked nystagmus (GEN), and perverted head-shaking nystagmus after taking a large dose of dapsone. These oculomotor abnormalities are assumed to be a reversible vestibulocerebellar dysfunction caused by over-dose of dapsone.
