A Case of Fungemia with Co-isolation of Candida parapsilosis and Trichosporon asahii Confirmed by MALDI-TOF MS and D2 rRNA Sequencing
- Author:
Jong Do SEO
1
;
Nam Hee KIM
;
Yun Ji HONG
;
Taek Soo KIM
;
Sang Mee HWANG
;
Jeong Su PARK
;
Moon Woo SEONG
;
Kyoung Un PARK
;
Junghan SONG
;
Sung Sup PARK
;
Eui Chong KIM
Author Information
- Publication Type:Case Report
- Keywords: Fungemia; Candida parapsilosis; Trichosporon asahii; MALDI-TOF MS; D2 rRNA sequencing
- MeSH: Candida; Catheters; Coinfection; Fever; Fungemia; Fungi; Humans; Hypotension; Incidence; Neutropenia; Parenteral Nutrition; Risk Factors; Shock, Septic; Sputum; Trichosporon; Tuberculosis, Pulmonary
- From:Laboratory Medicine Online 2019;9(2):88-93
- CountryRepublic of Korea
- Language:English
- Abstract: Fungi are a major cause of human infections with diverse clinical manifestations. The incidence of fungal infections has increased over time, particularly in patients who have risk factors such as neutropenia, immune suppression, an intravascular catheter, parenteral nutrition, a prosthetic device, and prior broad spectrum antibiotic therapy. Here, we present an unusual case of co-infection by 2 distinct fungi, Candida parapsilosis and Trichosporon asahii, isolated from a patient who did not have any known risk factors initially, except active pulmonary tuberculosis. Despite the negative conversion of sputum acid-fast bacilli (AFB) culture test after treatment, clinical symptoms were refractory to therapy. The patient developed symptoms suggesting septic shock, and 2 distinct colonies were isolated from a blood specimen, which were identified as C. parapsilosis and T. asahii by MALDI-TOF and rRNA sequencing. Fever and hypotension were relieved after anti-fungal agent injection, and pulmonary lesions identified by imaging also improved.
