Acute Lymphoblastic Leukemia Diagnosed in a Patient with Acromegaly.
10.3904/kjm.2016.90.3.243
- Author:
Young Seung OH
1
;
Min Seok CHOI
;
Jin Kyeong SHIN
;
Hee Sun KWON
;
Jang Won SON
;
Sung Rae KIM
;
Soon Jib YOO
Author Information
1. Department of Internal Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea, Bucheon, Korea. sjyoo@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Acromegaly;
Precursor cell lymphoblastic leukemia-lymphoma;
Insulin-like growth factor I
- MeSH:
Acromegaly*;
Adult;
Amenorrhea;
Biopsy;
Bone Marrow;
Bone Marrow Examination;
Bone Marrow Transplantation;
Breast;
Cell Count;
Dopamine Agonists;
Drug Therapy;
Female;
Fertility;
Follow-Up Studies;
Growth Hormone;
Hematologic Neoplasms;
Humans;
Incidence;
Insulin-Like Growth Factor I;
Lactation;
Precursor Cell Lymphoblastic Leukemia-Lymphoma*;
Prolactin;
Thyroid Neoplasms
- From:Korean Journal of Medicine
2016;90(3):243-247
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Acromegaly is a rare disorder caused by excessive amounts of growth hormone. The incidence of colorectal, breast, and thyroid carcinomas is increased in acromegaly. However, there have been few reports on hematological malignancies in acromegaly. We describe a patient who developed acute lymphoblastic leukemia during the course of acromegaly. A 35-year-old woman presented in February 2012 with unexplained lactation and amenorrhea for 4 months. Her growth hormone level was 12.6 microg/L, insulin-like growth factor 1 592.26 ng/mL, and prolactin 242 microg/L. A pituitary macroadenoma secreting GH and prolactin causing acromegaly was diagnosed. Considering her fertility, the dopamine agonist cabergoline 0.5 mg was administered in March 2012. In February 2014, she presented with cytopenia (hemoglobin 12.2 g/dL, white cell count 2.69 x 10(9)/L, platelets 39 x 10(9)/L) and hepatosplenomegaly. A bone marrow examination showed acute B cell lymphoblastic leukemia. She underwent chemotherapy and bone marrow transplantation. A follow-up bone marrow biopsy showed remission.
