The role of intercellular transfer of P-glycoprotein in tumor drug resistance
10.3760/cma.j.issn.1006-9801.2019.05.015
- VernacularTitle:细胞间P糖蛋白转移在肿瘤耐药中的作用
- Author:
Yongjun ZHENG
1
;
Huiliang ZHOU
Author Information
1. 宜春学院附属高安市人民医院泌尿外科 330800
- Keywords:
P-glycoprotein;
Drug resistance;
neoplasm;
Membranin transfer
- From:
Cancer Research and Clinic
2019;31(5):351-354
- CountryChina
- Language:Chinese
-
Abstract:
Multidrug resistance is a major cause of clinical failure of tumor chemotherapy, study on the mechanisms of tumor multidrug resistance has been becoming a fascinating area in the field of tumor chemotherapy. The tumor multidrug resistance is generally considered to be due to the gene mutation, amplification or epigenetic changes that affect the uptake , metabolism or excretion of tumor drugs . P-glycoprotein is a transmembrane glycoprotein encoded by multidrug resistance gene MDR1, which leads to the principal contributor to tumor multidrug resistance. Research suggests that P-glycoprotein can metastasize through the tumor cells, thereby affecting tumor resistance. This article reviews the role of intercellular transfer of P-glycoprotein in tumor drug resistance.
