Progress in research on the role of cannabinoid receptor 1 signaling pathway in epilepsy

VernacularTitle:大麻素受体1信号通路在癫痫中作用的研究进展
Author: Shiyu ZHU ¹ ; Yongli LU ; Hongwei YANG
Author Information

1. 三峡大学医学院生理与病理生理学系
Keywords: Epilepsy; Receptor,cannabinoid,CB1; Receptors,N-methyl-D-aspartate; Receptors,GABA
From: Chinese Journal of Neurology 2019;52(8):674-677
CountryChina
Language:Chinese
Abstract: Epilepsy,a group of chronic neurological disorders characterized by spontaneous and recurrent seizures and learning and memory impairments,results in transient brain dysfunction due to sudden abnormal discharge of brain neurons.The pathogenesis of epilepsy is very complicated and has not yet been fully elucidated.The imbalance between excitatory glutamate and inhibitory gamma-aminobutyric acid (GABA) neurotransmitters in the central nervous system and changes in ionic functions of N-methyl-D-aspartate receptors directly induce epileptic seizures.The endocannabinoid system plays an important role in retrograde synaptic transmission and exerts the anti-epileptic effect in cannabinoid receptor 1 (CBR1) dependent manner by regulating the synaptic transmission of glutamatergic and GABAergic neurons and homeostatsis of ionic channel function.Elucidating the specific mechanism of action of CBR1 signaling pathway in epilepsy,can provide an effective theoretical basis and novel drug's target for clinical treatment of epilepsy.