Optimization of Extraction Technology of Compound Danggui Buxue Decoction by Central Composite Design-Response Surface Method

VernacularTitle:中心组合设计-响应面法优化复方当归补血汤提取工艺
Author: Xiao MA ¹ ; Yong-Xin JIN ; Yu-Juan CHEN ; Lin-Qing YAO ; Rui-Tang ZHANG ; Peng-Fei XIA ; Hong-Mei ZHANG
Author Information

1. 甘肃省第二人民医院
Keywords: Compound Danggui Buxue Decoction; factorial design; central composite design-response surface method; extraction technology
From: Chinese Journal of Information on Traditional Chinese Medicine 2018;25(9):66-70
CountryChina
Language:Chinese
Abstract: Objective To optimize extraction technology of Compound Danggui Buxue Decoction. Methods On the basis of single factor test, factorial design, and fastest rise test, yield and weight sum of extraction efficiency of ferulic acid, paeoniflorin and ligustilide were set as response, and central composite design-response surface method was used to optimize the extraction technology of Danggui Buxue Decoction. Results The optimum conditions consisted of ultrasonic-wave extraction for 60 min, ethyl alcohol concentration 36％ and the ratio of material to solvent = 1:94. Conclusion This method has high extraction efficiency, easy operation and good predictability.