Meta-analysis on modified Zuogui Pill combined with hormone in the treatment of premature ovari-an failure
10.3760/cma.j.issn.1008-1372.2019.07.010
- VernacularTitle:左归丸加减方联合激素治疗卵巢早衰的Meta分析
- Author:
Cun JIAO
1
;
Xianjie LU
Author Information
1. 山东省聊城市人民医院中医科 252000
- Keywords:
Primary ovarian insufficiency;
ZUOGUI PILL;
Hormone replacement therapy;
Meta-a-nalysis
- From:
Journal of Chinese Physician
2019;21(7):1002-1006
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effectiveness and safety of modified Zuogui Pill combined with hormone in the treatment of premature ovarian failure ( POF) . Methods Randomized controlled trials were carried out by searching Chinese and English databases from the establishing to June, 2018. The meth-odological quality was assessed in the included randomized controlled trials. The treatment of premature o-varian failure by modified Zuogui Pill combined with hormone was systematically evaluated by RevMan 5. 3 software. Results 11 randomized controlled trials involving 1004 patients were included. Meta-analysis results showed that total effective rate (OR=4. 44, 95％ CI: 3. 10 -6. 36, P<0. 00001), Tranditional Chinese Medcine ( TCM ) syndromes ( including dizziness, tinnitus, hot flash night sweats, five upset fe-ver, waist and knees), serum follicle stimulating hormone ( FSH) level [ standardised mean difference (SMD) =0. 54, 95％ CI:0. 13-0. 95, P=0. 01], luteinizing hormone (LH) level (SMD=0. 90, 95％CI:0. 45-1. 36, P<0. 0001), estradiol (E2)level (SMD=1. 26, 95％ CI:0. 12-2. 40, P=0. 03), endometrial thickness [weighted mean difference (WMD) =2. 03, 95％ CI:0. 07-3. 99, P=0. 04] im-provement and the incidence of adverse reactions (OR=0. 34, 95％ CI:0. 12-0. 95, P=0. 04) in modi-fied Zuogui Pill combined with hormone therapy were superior to those of pure hormone therapy. Conclu-sions The modified Zuogui Pill combined with hormone therapy shows better therapeutic effect and safety than hormone therapy on premature ovarian failure.
