Correlation between influencing factors of cognitive dysfunction and event-related potentials in pa-tients with temporal lobe epilepsy
10.3760/cma.j.issn.1674-6554.2019.08.008
- VernacularTitle:颞叶癫痫患者认知功能障碍影响因素与事件相关电位的关系
- Author:
Taole LI
1
;
Lei LIU
;
Hong XU
Author Information
1. 昆明医科大学第一附属医院神经内科 650032
- Keywords:
Temporal lobe epilepsy;
Cognitive function;
Event-related potentials;
Influencing factors
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2019;28(8):710-715
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influencing factors of cognitive dysfunction in patients with temporal lobe epilepsy using event-related potential detection methods and to evaluate the correlation between them. Methods Sixty patients with temporal lobe epilepsy were enrolled according to the inclusion and ex-clusion criteria. Clinical data ( including age of onset,duration of disease,type of seizure,frequency of epi-sodes and anti-epileptic drugs) were collected. The determination of event-related potentials was improved for all patients enrolled. The latency of the N1,P2,N2,and P3 waves and the amplitude of the P3 wave are com-prehensively analyzed. Results Patients with temporal lobe epilepsy:the average latency of N1,P2,N2 and P3 and the average amplitude of P3 wave were ( 108. 47± 24. 58) ms,( 181. 70 ± 29. 63) ms,( 255. 63 ± 32. 66) ms,(367. 03±40. 43) ms and (6. 45± 5. 84) μV,respectively. ERPs (latency of P3 wave) of the age of onset ≤14 years old and the age of onset >14 years old group were statistically significant (P<0. 05). ERPs (latency of N2 wave and P3 wave) of course>5 years group and disease course≤5 years group were statistically significant (P<0. 05). There was significant difference in ERPs (P3 wave amplitude) between the general seizure group and the partial seizure group (P<0. 05). ERPs (latency of P3 wave) frequency of seizures >4 times/month group and≤4 times/month group were statistically significant (P<0. 05); ERPs (latency of N2 wave) of combination group and monotherapy group was statistically significant (P<0. 05). The course of the temporal lobe epilepsy and medicine therapy of combination were impact factors of the la-tency of N2 wave (P<0. 05). Temporal seizure frequency,age of onset and course of disease were impact fac- tors of P3 wave (P<0. 05). Conclusion Age of onset,the course of the temporal lobe epilepsy,the type of seizures,the frequency of seizures and the anti-epileptic drugs are important influencing factors of cognitive dysfunction in patients. In event-related potentials,they have different effects on different stages of cognition.
