Advances in the regulation mechanism of cholinergic anti-inflammatory pathway on sepsis
10.3760/cma.j.issn.2095-4352.2019.06.024
- VernacularTitle:胆碱能抗炎通路对脓毒症调控机制的研究进展
- Author:
Qingxiang LIU
1
;
Jianfeng XIE
;
Yi YANG
Author Information
1. 东南大学附属中大医院重症医学科
- Keywords:
Sepsis;
Inflammatory response;
Cholinergic anti-inflammation pathway;
Vaginal nerve
- From:
Chinese Critical Care Medicine
2019;31(6):781-784
- CountryChina
- Language:Chinese
-
Abstract:
Excessive or persistent inflammatory response is an important pathophysiological feature of sepsis, and the tissue damage and organ dysfunction caused by sepsis are related to the prognosis of patients. The cholinergic anti-inflammatory pathway releases acetylcholine (ACh) through the vaginal nerve and acts on the surface of the inflammatory cell α7 nicotine acetylcholine receptor (α7nAChR) to inhibit the production of inflammatory factors, so that the inflammatory response tends to be balanced. This article reviews the composition and effects of cholinergic anti-inflammatory pathways, the mechanism of regulating sepsis and its clinical application, in order to provide a new direction for the treatment of sepsis.
