Clinical analysis of 166 cases of bacterial/fungal bloodstream infection in AIDS patients
10.16718/j.1009-7708.2018.06.003
- VernacularTitle:获得性免疫缺陷综合征合并细菌或真菌性血流感染166例临床分析
- Author:
Xiaoqing HE
1
;
Min LIU
;
Yanqiu LU
;
Li CHEN
;
Yaokai CHEN
Author Information
1. 重庆市公共卫生医疗救治中心感染科
- Keywords:
acquired immunodeficiency syndrome;
bloodstream infection;
bacterial;
fungal;
intravenous drug abuse
- From:
Chinese Journal of Infection and Chemotherapy
2018;18(6):574-578
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the clinical characteristics and outcomes of bacterial and fungal bloodstream infections in the patients with acquired immunodeficiency syndrome (AIDS). Methods The clinical data of AIDS patients complicated with bacterial or fungal bloodstream infection treated in Chongqing Public Health Medical Center from January 2016 to June 2018 were analyzed retrospectively. The two groups of patients were compared in terms of clinical symptoms, laboratory tests and outcomes. Results Significantly more patients in bacterial group (AIDS complicated with bacterial bloodstream infection) were associated with intravenous drug abuse than that in fungal group (AIDS complicated with fungal bloodstream infection) (P＜0.05). The average age of patients was older in bacterial group than in fungal group. The incidence of nausea, vomiting and skin rash in fungal group was significantly higher than that in bacterial group (P＜0.05). CD4+T cells in fungal group decreased more significantly than that in bacterial group. No significant difference was found between the two groups in sex ratio, routine blood tests, biochemical assays, and mortality. Conclusions Fungi are the main pathogen of AIDS-associated bloodstream infections. Contrast to the bacterial bloodstream infections in AIDS patients, fungal bloodstream infection is more frequently found in younger patients, and associated with higher incidence of nausea, vomiting, typical skin rash, and more remarkable decrease of CD4+T cells. Bacterial bloodstream infection is more prevalent than fungal bloodstream infection in intravenous drug abusers. No significant difference is found in the mortality between the AIDS patients complicated with bacterial bloodstream infection and those complicated with fungal bloodstream infection.
