Comparison of clinical characteristics between diffused capillary endothelial proliferative Henoch-Sch?nlein purpura nephritis children with and without crescents formation
10.3760/cma.j.issn.1673-4904.2019.05.009
- VernacularTitle:弥漫毛细血管内皮增生性紫癜性肾炎患儿是否伴发新月体形成的临床特征对比
- Author:
Yan LIU
1
;
Ping LIU
;
Fan YANG
Author Information
1. 陕西省商洛市妇幼保健计划生育服务中心儿科 726000
- Keywords:
Glomerulonephritis;
Purpura,Schoenlein-Henoch;
Child;
Retrospective studies
- From:
Chinese Journal of Postgraduates of Medicine
2019;42(5):414-417
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics of diffused capillary endothelial proliferative Henoch-Sch?nlein purpura nephritis (DEP-HSPN) children with or without crescents formation. Methods The clinical data of 110 DEP-HSPN children diagnosed by renal biopsy from February 2013 to June 2017 in Shangluo Maternal and Child Health Family Planning Service Center were retrospectively analyzed. Among them, 24 cases had no crescents formation (group A), and 86 cases had crescents formation (group B). The children of 2 groups were treated with standard regimen, and the clinical characteristics and prognosis between 2 groups were compared. Results The rates of Ⅴ type and gross hematuria in group B were significantly higher than those in group A: 59.3% (51/86) vs. 0 and 83.7% (72/86) vs. 29.2% (7/24), the levels of urine red blood cell count, 24 h urine protein and serum creatinine were significantly higher than those in group A: (112.4 ± 20.3)/HP vs. (45.2 ± 10.6)/HP, (2 471.6 ± 242.0) mg vs. (1 358.5 ± 109.3) mg and (44.9 ± 9.6) μmol/L vs. (32.3 ± 5.2) μmol/L, the level of serum albumin was significantly lower than that in group A: (22.8 ± 3.8) g/L vs. (35.1 ± 5.7) g/L, and there were statistical differences (P＜0.01 or ＜0.05). There were no statistical differences in rate of nephrogenous albuminuria, glomerular pathology type and immunoglobulin deposition condition between 2 groups (P＞0.05). There were 17 cases of complete remission and 7 cases of asymptomatic hematuria in group A, and 50 and 36 cases in group B, respectively. There was no significant difference between 2 groups (P > 0.05). Conclusions When DEP-HSPN is accompanied by crescent formation, gross hematuria, urine red blood cell count and the proportion of massive albuminuria can increase significantly. Combination therapy with immunosuppressive agents in acute stage and long- term sequential treatment could achieve good prognosis.
