Influence of ticagrelor on myocardial injury in patients with acute myocardial infarction after emergen-cy PCI
10.3969／j.issn.1008－0074.2019.03.20
- VernacularTitle:替格瑞洛对急性心肌梗死急诊 PCI 术后患者心肌损伤的影响
- Author:
Yi-Fu SHI
1
;
Jie LIANG
;
Rong-Li HAN
;
Yan-Jun HU
;
Yan ZHANG
Author Information
1. 上海市徐汇区大华医院心内科
- Keywords:
Myocardial infarction;
Angioplasty,balloon,coronary;
Ticagrelor;
Clopidogrel
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2019;28(3):341-344
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To explore influence of ticagrelor on myocardial injury ,serum levels of N terminal pro brain natriuretic peptide (NT-proBNP) ,tumor necrosis factor (TNF)-α and endothelin (ET) in patients with acute myo-cardial infarction (AMI) after emergency percutaneous coronary intervention (PCI).Methods : A total of 94 AMI patients undergoing emergency PCI were selected ,and were divided into clopidogrel group (n＝ 45 ) and ticagrelor group (n＝ 49 ) ,two groups received postoperative dual-antiplatelet therapy of aspirin combined clopidogrel or ti-cagrelor respectively .After one-month treatment ,index of microcirculatory resistance (IMR ) ,coronary flow re-serve (CFR ) , serum levels of NT-proBNP , TNF-α , ET , and incidence of major adverse cardiovascular events (MACE) within one year were compared between two groups .Results : Compared with clopidogrel group after 12- month treatment ,there were significant reductions in IMR [21-24 ± 4-07 ) vs.(15-33 ± 4-82)] ,serum levels of NT-proBNP [(123-17 ± 16-25) ng／L vs.(63-46 ± 12-13) ng／L] ,TNF-α [(4-04 ± 0-84) mg／L vs.(3-07 ± 0-52) mg／L] ,ET-1 [ (48-71 ± 6-53) ng／L vs.(38-04 ± 5-89) ng／L] ,and significant rise in CFR [ (1-73 ± 0-34) vs. (2-36 ± 0-42)] in ticagrelor group , P＝ 0-001 all .Incidence rate of MACE in ticagrelor group was significantly lower than that of clopidogrel group (6-12% vs .24-44%, P＝ 0-018 ).Conclusion : Compared with clopidogrel group ,ticagrelor group possesses significant therapeutic effect in AMI patients after emergency PCI .And it′s safe .
