Influence of nicorandil on vascular endothelial function and serum inflammatory reaction in CHD pa-tients undergoing PCI
10.3969／j.issn.1008－0074.2019.03.19
- VernacularTitle:尼可地尔对行 PCI 冠心病患者血管内皮功能及血清炎性反应的影响
- Author:
Zu-Xia LIU
1
;
Bin ZHANG
;
Wei WANG
;
Kang-Lin ZHANG
;
Xi HUANG
;
Jun-Li HUANG
Author Information
1. 武汉市黄陂区人民医院心内科／江汉大学附属第三医院心内科
- Keywords:
Coronary disease;
Angioplasty,balloon,coronary;
Nicorandil
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2019;28(3):337-341
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To study influence of nicorandil on vascular endothelial function and serum inflammatory reac-tion in patients with coronary heart disease (CHD) undergoing percutaneous coronary intervention (PCI).Methods :A total of 118 CHD patients undergoing PCI in our hospital were randomly divided into routine treatment group (n＝58) and nicorandil group (n＝60 ,received nicorandil based on routine treatment ) ,both groups were treated for six months .Endothelial function ,levels of inflammatory factors and myocardial injury markers before and after treatment ,and incidence of major adverse cardiovascular events (MACE) were observed and compared between two groups.Results : Compared with routine treatment group after treatment ,there were significant rise in radial artery reactive hyperemia inner diameter [D1 ,(3-83 ± 0-37) mm vs.(4-01 ± 0-39) mm] ,flow-mediated dilation of bra-chial artery [FMD ,(14-33 ± 1-42 )% vs.(19-35 ± 1-95 )%] ,serum levels of nitric oxide [NO , (70-72 ± 7-82 ) μmol／L vs .(86-15 ± 8-52) μmol／L] and interleukin-10 [IL-10 ,(392-86 ± 40-19) ng／ml vs.(472-75 ± 48-62) ng／ml] ,and significant reductions in serum levels of endothelin-1 [ET-1 ,(70-29 ± 7-39) ng／L vs.(59-62 ± 6-02) ng／L ] ,intercellular adhesion molecule-1 [ICAM-1 ,(195-68 ± 20-48) μg／L vs.(146-72 ± 15-07) μg／L] ,cardiac tropo-nin I [cTnI ,(0-471 ± 0-071) ng／ml vs.(0-222 ± 0-052) ng／ml] ,creatine kinase isoenzyme MB [CK-MB ,(27-62 ± 3-72) U／L vs.(14-79 ± 1-52) U／L] ,mean platelet volume [MPV ,(10-26 ± 1-06) fl vs.(9-75 ± 0-95) fl] ,high sensitive C reactive protein [hsCRP , (5-36 ± 0-63 ) mg／L vs.(3-08 ± 0-27 ) mg／L ] , in-stent restenosis rate (20-69% vs.1-67%) and incidence rate of MACE (67-24% vs.10-00%) in nicorandil group ,P＜0-05 or ＜0-01-Conclusion : Nicorandil can improve postoperative endothelial function ,reduce inflammatory reaction ,protect myo-cardial cells with good prognosis in CHD patients undergoing PCI ,which is worth extending .
