Clinical study of sympathetic activity in aged hypertensive patients with left ventricular hypertrophy
10.3969／j.issn.1008－0074.2019.03.10
- VernacularTitle:老年高血压合并左室肥厚患者交感神经活性的临床研究
- Author:
Ji-Xiong CHEN
1
;
Xiao-Yan HUANG
;
Ping WANG
;
Wen-Ting LIN
;
Xiu-Hong FU
;
Yang-Li HE
;
Min ZENG
Author Information
1. 海南省人民医院保健中心三区
- Keywords:
Hypertension;
Hypertrophy,left ventricular;
Sympathetic nervous system
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2019;28(3):301-306
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To study sympathetic activity in aged patients with essential hypertension (EH) complicated left ven-tricular hypertrophy (LVH).Methods : A total of 248 aged EH patients were selected from our hospital from Jun 2015 to Jun 2017- According to blood pressure level ,they were divided into EH stage 1 group (n＝78) ,stage 2 group (n＝89) and stage 3 group (n＝81).According to presence of LVH ,patients were divided into no LVH group (n＝122) and complicat-ed LVH group (n＝126).According to blood pressure level ,LVH patients were divided into stage 1 group (n＝28) ,stage 2 group (n＝41) and stage 3 group (n＝57).Another 130 healthy aged people undergoing physical examination were regar-ded as normal aged group .Plasma norepinephrine (NE) and epinephrine (E) contents were measured and compared among all groups ,and 24h DCG was performed.Results :Compared with normal aged group ,there were significant rise in plasma contents of NE [ (238-33 ± 18-04) ng／L vs.(312-90 ± 23-20) ng／L ,(279-28 ± 20-85) ng／L] ,E [ (262-86 ± 24-56) ng／L vs.(366-57 ± 25-53) ng／L ,(301-20 ± 23-80) ng／L] in complicated LVH group and no LVH group ( P＝0-001 all) ,and plasma NE and E contents gradually and significantly rose along with blood pressure stage rose , P＝0-001 all. Compared with normal aged group ,there was significant rise in mean heart rate [ (64-80 ± 5-40) beats／min vs.(69-02 ± 4-56) beats／min ,(66-72 ± 4-98) beats／min] in complicated LVH group and no LVH group ( P＝0-001 ,0-017) ;signif-icant reductions in SDNN [ (122-07 ± 7-73) ms vs.(109-51 ± 8-13) ms ,(99-25 ± 7-89) ms] ,SDANN [ (111-72 ± 13-33) ms vs.(103-52 ± 10-41) ms ,(94-78 ± 8-75) ms] ,rMSSD [ (43-98 ± 6-31) ms vs.(37-25 ± 6-42) ms ,(32-05 ± 5-19) ms] and PNN50 [ (7-67 ± 0-71)% vs.(5-41 ± 0-67)%,(3-39 ± 0-63)%] in no LVH group and complicated LVH group , P＝0-001 all ,above indexes gradually and significantly reduced along with blood pressure stage rose , P＝0-001 all.Conclusion :Sympathetic activity significantly elevates in aged EH + LVH patients.Controlling sympathetic ac-tivity will help to improve prognosis .
