Influence of different doses of clopidogrel combined aspirin on platelet related indexes and safety in UAP patients
10.3969/j.issn.1008－0074.2019.02.13
- VernacularTitle:不同剂量氯吡格雷联合阿司匹林对 U AP 患者血小板相关指标及安全性的影响
- Author:
Boer AN
1
;
Fenglan ZHOU
;
Yafang ZHANG
Author Information
1. 首都医科大学宣武医院药剂科
- Keywords:
Angina,unstable;
Aspirin;
Clopidogrel
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2019;28(2):181-184
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To explore influence of different doses of clopidogrel combined aspirin on platelet related inde—xes and safety in patients with unstable angina pectoris (UAP).Methods : A total of 92 UAP patients treated in our hospital were randomly and equally divided into large dose clopidogrel combined group (received 150mg／d clopi—dogrel combined aspirin ) and routine dose clopidogrel combined group (received 75mg／d clopidogrel combined aspi—rin) ,both groups were continuously treated for three months .Therapeutic effect , medication safety , level of thrombolytic granule membrane protein (GMP)—140 ,maximum platelet aggregation rate (LTA—PAmax ) and ADP—induced maximum platelet amplitude (MAADP ) were compared between two groups .Results : After three—month treatment ,there were no significant difference in total effective rate ,incidence rate of major adverse cardiovascular events ,GMP—140 level ,LTA—PAmax and MAADP between two groups , P＞0. 05 all.Incidence rate of severe hemor—rhage in large dose clopidogrel group was higher than that of routine dose group (6.52% vs.2. 17%) without signifi—cant difference ( P＝0.609).Conclusion : Increased dose of clopidogrel combined aspirin doesn＇t obtain significant therapeutic effect ,but may be risk of hemorrhage for unstable angina pectoris ,which calls for clinical attention
