Modified Liumo decoction and polyethylene glycol 4000 powder in the treatment of functional constipation with Qi stagnation type
10.3760/cma.j.issn.1673-4246.2019.06.009
- VernacularTitle:加味六磨汤结合聚乙二醇4000散治疗气滞型功能性便秘
- Author:
Yujia WANG
1
;
Hong SHEN
Author Information
1. 南京中医药大学 210023
- Keywords:
Constipation;
Functional;
Qi stagnation syndrome;
Neurotransmitter drugs (TCD);
Modified Liumo decoction;
Polyethylene glycol 4000 powder
- From:
International Journal of Traditional Chinese Medicine
2019;41(6):585-588
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of modified Liumo decoction combined with polyethylene glycol 4000 powder in the treatment of functional constipation (FC) with Qi stagnation type.Methods A total of 92 FC patients who met the inclusion criteria were divided into two groups by random number table method,46 in each group.The control group was treated with polyethylene glycol 4000 powder orally on the basis of routine treatment.The treatment group was treated with modified Liumo decoction on the basis of the control group.Both groups were treated for 4 weeks and followed up for 6 months.TCM syndrome was scored before and after treatment.The Serum levels of NOS,NO,SOD,MDA and glutathione (GSH) were detected by ELISA.The adverse reaction during treatment was observed and the recurrence rate was calculated.Results After treatment,the score of defecation discomfort,abdominal distention,bowel ringing,sagittal frequency and chest and rib fullness in the treatment group was significantly lower than those in the control group (t=-4.749,-5.140,-5.835,-6.883,-6.919,all Ps＜0.01).The level of serum NOS (26.95 ± 5.11 U/ml vs.31.36± 7.61 U/ml,t=-3.263),NO (61.91 ± 12.62 U/ml vs.72.35 ± 12.03 U/ml,t=-4.061) in the treatment group was significantly lower than those in the control group (P＜0.01),the level of serum SOD (24.66 ± 3.82 U/ml vs.21.39 ± 3.41 U/ml,t=4.331),GSH (12.15 ± 1.52 U/ml vs.8.13 ± 1.42 U/ml,t=-1 3.278) in the treatment group was significantly higher than those of the control group (P＜0.01),while the MAD level (2.73 ± 0.83 U/ml vs.4.92 ± 0.75 U/ml,t=13.108) in the treatment group was significantly lower than that in the control group (P＜0.01).After 6 months of follow-up,the recurrence rate of the control group was 27.3％ (9/33),which was significantly higher than 4.8％ (2/42) of the treatment group,and the difference was statistically significant (x2=7.482,P=0.006).Conclusions The modified Liumo decoction combined with polyethylene glycol 4000 powder can improve the levels of intestinal neurotransmitters,SOD,MDA and GSH in patients with FC,alleviate the symptoms of traditional Chinese medicine and reduce the recurrence rate.
