Progress of tumor-educated platelets in tumor diagnosis
10.3760/cma.j.issn.1673-4203.2019.07.015
- VernacularTitle:肿瘤相关血小板在肿瘤诊断中的研究进展
- Author:
Fan YANG
1
;
Xiaoping ZHAO
;
Jianping GONG
Author Information
1. 赤水市人民医院普通外科 564700
- Keywords:
Neoplasms;
Tumor-educated platelets;
Diagnosis;
Liquid biopsy
- From:
International Journal of Surgery
2019;46(7):501-504
- CountryChina
- Language:Chinese
-
Abstract:
Platelets,which are derived from the multifunctional hematopoietic stem cells in the hematopoietic system of bone marrow,are small pieces of cytoplasm which was partially exfoliated from the bone marrow megakaryotic cells,and play an important role in the physiological hemostasis and coagulation process.Tumor cells transfer biomolecules (such as RNA) to platelets by direct contact or exosomes release,resulting in changes in platelet precursor RNA.Through the effect of tumor cells and microenvironment,precursor RNA of platelet is spliced to mature RNA and then transformed into functional protein to responds to external stimulation,which is forming tumor-educated platelets.The detection of tumor-educated platelets of peripheral blood of patients is expected to be used in clinical tumor diagnosis.The novel liquid biopsy method can be a replacement or supplement for current tumor detection methods.Further study of the role of tumor-educated platelets in the diagnosis of tumors will provide a new theoretical basis for clinical diagnosis of tumors.
