Recent advances in the application of quaternary ammonium compounds in biomedical materials
10.12016/j.issn.2096-1456.2019.05.002
- Author:
JIAO Yang
1
;
CHEN Jihua
2
Author Information
1. Department of Stomatology, 7th Medical Center of PLA General Hospital
2. State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shanxi Key Laboratory of Oral Diseases, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University
- Publication Type:Journal Article
- Keywords:
Quaternary ammonium compound;
Antibacterial;
Orthopedics-related materials;
Sutures;
Wound dressings;
Dental materials;
Cytotoxicity;
Matrix metalloproteinase
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2019;27(5):280-286
- CountryChina
- Language:Chinese
-
Abstract:
Microbial infections affect people worldwide. Quaternary ammonium salts serve antibacterial, antifungal, antiviral, anti-matrix metalloproteinase and polymerization functions. While the modification of biomaterials with quaternary ammonium salts cannot affect the physical or chemical properties of the biomaterials, this process can confer them with stable biological activity. Currently, quaternary ammonium salts are widely used in the development of functional orthopedic materials, sutures, dressings and dental materials, and the idea of modifying biomedical materials with quaternary ammonium salts has become the most promising, e.g., for preparing antimicrobial biomaterials. Recent studies have found that quaternary ammonium salt-modified antimicrobial monomers are cytotoxic. Therefore, it is of great significance to explore the cytotoxic mechanism of quaternary ammonium salt-modified antimicrobial monomers and determine possible cytoprotective measures for improving the biological safety of these antimicrobial resin-based materials and expanding their clinical applications. In addition, further validation of the clinical efficacy of these biomaterials is particularly important for accurately evaluating the clinical prospects of these biomaterials. Based on a literature review, this paper summarizes the applications and toxicity of biomedical materials modified with quaternary ammonium salts.
- Full text:季铵盐化合物在生物医学材料中的应用进展.pdf
