Classification of chronic rhinosinusitis according to a nasal polyp and tissue eosinophilia: limitation of current classification system for Asian population
10.5415/apallergy.2017.7.3.121
- Author:
Sung Woo CHO
1
;
Dae Woo KIM
;
Jeong Whun KIM
;
Chul Hee LEE
;
Chae Seo RHEE
Author Information
1. Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam 13620, Korea. csrhee@snu.ac.kr
- Publication Type:Review
- Keywords:
Sinusitis;
Classification;
Nasal polyps;
Eosinophilia;
Caucasians;
Asians
- MeSH:
Asian Continental Ancestry Group;
Classification;
Eosinophilia;
Eosinophils;
Far East;
Humans;
Nasal Polyps;
Sinusitis
- From:
Asia Pacific Allergy
2017;7(3):121-130
- CountryRepublic of Korea
- Language:English
-
Abstract:
Chronic rhinosinusitis (CRS) can be classified according to the presence of a nasal polyp (NP): CRS with NP (CRSwNP) and CRS without NP (CRSsNP). CRSwNP has characteristics with high infiltration of tissue eosinophilia with a burst of Th2 inflammatory cytokine. However recent findings in Eastern Asia countries suggest that CRSwNP can be divided according to the presence of tissue eosinophilia. Thus, CRSwNP can be classified into eosinophilic and noneosinophilic. Eosinophilic CRSwNP seems to have different immunological and clinical feature compared to noneosinophilic CRSwNP. From the same point of view, CRSsNP can also be divided according to tissue eosinophilia. However, the meaning of this dichotomous categorization in CRS seems to be not quite clear. This review focus on the limitations in current subclassification of CRS according to the presence of NP and tissue eosinophilia and discuss other factors related to tissue remodeling and NP generation which may provide clues for the further understanding of CRS pathogenesis.
