Current research situation of the characteristics of recurrent optic neuritis and the pathogenesis of optic neuritis
10.3760/cma.j.issn.1005-1015.2019.03.020
- VernacularTitle:复发性视神经炎的临床特点及视神经炎发病机制的研究现状
- Author:
Xuemei LIANG
1
;
Shan CAO
Author Information
1. 南宁爱尔眼科医院
- Keywords:
Optic neuritis/etiology;
Review;
Recurrent optic neuritis
- From:
Chinese Journal of Ocular Fundus Diseases
2019;35(3):295-298
- CountryChina
- Language:Chinese
-
Abstract:
Optic neuritis (ON) is one of the symptom of a central nervous system demyelinating,systemic or infectious disease.The pathogenetic mechanism of ON is still not completely clear,and its core is inflammation and immune that occurred in the optic nerve axons,and apoptosis of RGC was induced.Few patients experience recurrent episodes after treatment,presenting a remission-recurrence course of polyphasic disease,named recurrent ON (RON).Two forms of RON have been assigned:recurrent isolated optic neuritis,which is a chronic corticosteroid-dependent optic neuropathy with intermittent acute relapses,and recurrent isolated optic neuritis,which is a non-progressive relapsing ON without steroid dependence.Recurrence of ON causes cumulative damage to the optic nerve lesions and impaired visual signal transmission,thus causing irreversible damage to vision.Therefore,it is very important to have a deep understanding of the pathogenesis of ON and the clinical characteristics of RON,so as to better conduct clinical treatment.
