Risk factors for recurrence of lateral cervical lymph node metastasis in papillary thyroid cancer: analysis of 617 patients at a single institution
10.3760/cma.j.issn.1007-631X.2019.03.011
- VernacularTitle:甲状腺乳头状癌侧颈淋巴结转移的复发危险因素:单中心617例分析
- Author:
Siyuan XU
1
;
Jie LIU
;
Hui HUANG
;
Zongmin ZHANG
;
Shaoyan LIU
;
Xiaolei WANG
;
Zhengang XU
Author Information
1. 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院头颈外科
- Keywords:
Thyroid neoplasms;
Lymphatic metastasis;
Recurrence
- From:
Chinese Journal of General Surgery
2019;34(3):230-234
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore risk factors for posttreatment recurrence of lateral cervical lymph node metastasis in papillary thyroid cancer (PTC).Methods The clinical data of 617 consecutive PTC patients with initial presentation of lateral neck metastasis (N1b) at the time of surgery from 1996 to 2009 in our department were retrospectively reviewed.All of the cases received surgery and postoperative L-thyroxine therapy,81 patients were administered postoperative radioactive iodine adjuvant therapy.The risk factors for recurrence including local recurrence and distant metastasis were determined using both univariate and multivariate analyses considering several clinicopathologic variables.Results The median follow-up period was 93 months,466 and 134 patients were followed up for more than 5 and 10 years respectively.148 (24.0％) patients experienced recurrence with 28 (4.5％) death.Multivariate analyses revealed that age (≥55 years),primary tumor size,the size of metastatic lymph nodes (＞3 cm) were independent risk factors of local recurrence and distant metastasis (P ＜ 0.05).The numbers of metastatic lymph nodes (＞ 10) was the risk factor of local recurrence in patients with N1bPTC (P =0.001;RR =2.022).Conclusion Age,primary tumor size,the size of metastatic LN and the numbers of LN metastases were independent risk factors for recurrence.
