Effects of Jinghua Weikang capsule combined with triple therapy in the treatment of Helicobacter pylori positive verrucous gastritis
10.3760/cma.j.issn.1008-6706.2019.06.001
- VernacularTitle:荆花胃康胶丸联合三联疗法治疗幽门螺杆菌阳性疣状胃炎的 效果观察
- Author:
Li LIU
1
Author Information
1. 山西大同大学附属医院消化内科 037005
- Keywords:
Gastritis;
Helicobacter pylori;
Jinghua Weikang Jiaowan;
Drug therapy;
combination
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(6):641-645
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical effect of Jinghua Weikang capsule combined with proton pump inhibitor(PPI) triple therapy in the treatment of Helicobacter pylori ( Hp) positive verrucous gastritis. Methods From January 2013 to March 2017,120 patients with Hp positive verrucous gastritis who admitted to the Affiliated Hospital of Shanxi Datong University were selected,and they were randomly divided into control group and observation group,with 60 cases in each group. The control group was treated with PPI triple therapy,and on the basis,the observation group was treated with Jinghua Weikang capsule. The curative effects were compared between the two groups,and the improvement of symptoms and signs were assessed. The Hp eradication rate was statistically analyzed,and the adverse drug reactions were recorded. All patients were followed up for 6 months,and the recurrence rate in the two groups after drug withdrawal was statistically analyzed. Results The total effective rate of the observation group was higher than that of the control group(95. 00％ vs. 80. 00％ ) (χ2 = 6. 171,P < 0. 05). After treatment,the scores of upper abdominal pain,anorexia,acid reflux,belching and abdominal distension in the two groups were decreased(all P <0. 05), and the symptom scores in the observation group were lower than those in the control group[(0. 42 ± 0. 20)points, (0. 34 ± 0. 15)points,(0. 51 ± 0. 32)points,(0. 42 ± 0. 31)points,(0. 33 ± 0. 21)points vs. (1. 26 ± 0. 41)points, (0. 97 ± 0. 33)points,(1. 02 ± 0. 17) points,(0. 96 ± 0. 25) points,(1. 02 ± 0. 32) points] (t = 14. 263,13. 462, 10. 902,9. 911,13. 963,all P <0. 05). The Hp negative rate in the observation group was higher than that in the control group(93.33％ vs.76.67％)(χ2 =6. 535,P < 0. 05). But there was no statistically significant difference in the incidence rate of adverse reactions between the two groups(10. 00％ vs. 6. 67％ )(χ2 = 0. 436,P > 0. 05). The recurrence rates of Hp infection in the observation group at 3 months and 6 months after drug withdrawal were lower than those in the control group(6. 67％ ,8. 33％ vs. 20. 00％ ,23. 33％ ) (χ2 = 4. 615,5. 065,all P < 0. 05). Conclusion Jinghua Weikang capsule combined with PPI triple therapy can improve the curative effect of Hp positive verrucous gastritis, improve symptom scores,the Hp eradication rate and reduce the recurrence rate after drug withdrawal,with high safety.
